Mite allergen is a danger signal for the skin via activation of inflammasome in keratinocytes

Article ID	Journal	Published Year	Pages	File Type
6067107	Journal of Allergy and Clinical Immunology	2011	13 Pages	PDF

Abstract

House dust mite allergens are danger signals for the skin. In addition, HDM-induced activation of the NLRP3 inflammasome may play a pivotal role in the pathogenesis of AD.

Keywords

ASC shRNAs zVAD E-64 Dermatophagoides pteronyssinus Nlrp Short hairpin RNAs caspase-1 NLRP3 phorbol 12-myristate 13-acetate NF-κB HDM NLR IL-18 PAR2 HMGB1 TLR IL-1β PMA Der p 1 PolyI:C Inflammasome Toll-like receptor Atopic dermatitis nuclear factor-κB High-mobility group box protein 1 polyinosinic-polycytidylic acid Keratinocytes House dust mite protease-activated receptor 2

Related Topics

Life Sciences Immunology and Microbiology Immunology

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Mite allergen is a danger signal for the skin via activation of inflammasome in keratinocytes

Authors

Xiuju MD, PhD, Koji MD, PhD, Mikiko MD, PhD, Yuji MD, PhD, Yasushi MD, PhD, Sho MD, PhD, Lujun MD, PhD, Satoshi MD, PhD, Koji MD, PhD,