| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6067909 | Journal of Allergy and Clinical Immunology | 2008 | 10 Pages |
Abstract
We have isolated a new class of druglike compounds that modulate the interaction of Syk with some of its macromolecular substrates implicated in the degranulation pathway in mast cells.
Keywords
PI3KPSAscFvC-13PTKSLP-76PLC-γBMMCITAMSH2PCApassive systemic anaphylaxisPassive cutaneous anaphylaxisSykTyrosine kinaseLATBone marrow–derived mast cellMast cells/basophilsAnaphylactic shockspleen tyrosine kinasePhosphatidylinositol 3-kinasephospholipase CγDegranulationLinker for activation of T cellsimmunoreceptor tyrosine-based activation motifSrc Homology 2Protein tyrosine kinase
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Authors
Elsa MSc, Bruno O. PhD, Odile MSc, Thomas PhD, Sébastien Fleury, Jean-Paul PhD, David PhD, Marc MD, PhD, Pierre PhD, Piona PhD,