Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6069743 | Journal of the American Academy of Dermatology | 2016 | 10 Pages |
Abstract
Both inherited and acquired hypercoagulable states can present with nonspecific clinical manifestations, such as petechiae, purpura, livedo reticularis, and ulcerations. A good history and physical examination are crucial to diagnoses of these conditions. Inherited conditions tend to present either in neonatal period or later in life, while acquired conditions typically occur later in life. Diagnostic studies are performed to identify the coagulation cascade deficiency or defect. Treatment primarily hinges on anticoagulation and wound care. In this article, we provide an in-depth analysis of the clinical manifestations, diagnostic considerations, and management options of patients in hypercoagulable states.
Keywords
PTTINRVTETTPAPCLMWHSCDFVLAntithrombin III deficiencyLivedoid vasculopathyAtrophie blancheAPsantithrombinHITLower extremitySickle cell diseaseVenous thromboembolismThrombosisDVTDeep vein thrombosisHeparin-induced thrombocytopeniaThrombotic thrombocytopenia purpuraThrombophiliaELISAEnzyme-linked immunosorbent assayhypercoagulable stateulcersPartial thromboplastin timeprothrombin timeAntiphospholipid syndromeFactor V leiden mutationFactor V LeidenInternational Normalized RatioLow molecular weight heparinHyperhomocysteinemiapolymerase chain reactionPCRActivated protein CProtein C deficiencyProtein S deficiency
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Authors
Ganary MD, PhD, Elizabeth MD, Yunyoung MD, Emily MD, Jennifer Gloeckner MD, Tania MD,