Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6069901 | Journal of the American Academy of Dermatology | 2016 | 15 Pages |
Abstract
Nonmelanoma skin cancers (NMSCs) represent the most common malignancies worldwide, with reported incidence rising each year. Both cutaneous squamous cell carcinoma (SCC) and basal cell carcinoma (BCC), as well as other NMSCs, represent complex diseases with a combination of environmental and genetic risk factors. In general, hereditary cancer syndromes that increase the risk of NMSC fall under several broad categories: those associated with immunodeficiencies, those that affect skin pigmentation, and those that perturb key molecular pathways involved in the pathogenesis of NMSCs. Many of the syndromes are also associated with extracutaneous manifestations, including internal malignancies; therefore, most require a multidisciplinary management approach with a medical geneticist. Finally, dermatologists play a critical role in the diagnosis and management of these conditions, because cutaneous findings are often the presenting manifestations of disease.
Keywords
Patched1SLC45A2OCAHNPCCMLH1OCA2MSSEMSH2MSH6PMS2SLC24A5MutS homolog 6UVRDFSPPTCH1SMONMSCTYRP1BCNSADA-SCIDSufu5-FUSCCRothmund–Thomson syndromeRTSBCCRECQL4MTSMuir–Torre SyndromeMutS homolog 2MSIMMRADA1TGFBR1natural killerMutL homolog 1xeroderma pigmentosumGenetic testingoculocutaneous albinismUltraviolet radiationepidermodysplasia verruciformisIHCImmunohistochemistryMicrosatellite instabilitytransforming growth factor beta receptor 1mismatch repairTyrTyrosinaseShhDermatofibrosarcoma Protuberansnonmelanoma skin cancerHereditary nonpolyposis colon cancerBloom syndromebasal cell nevus syndromeWerner syndromeGorlin SyndromeSmoothenedsonic hedgehog5-fluorouracilHuman papillomavirusHPVtyrosinase-related protein 1Basal cell carcinomaSquamous cell carcinomaDyskeratosis congenita
Related Topics
Health Sciences
Medicine and Dentistry
Dermatology
Authors
Prajakta D. BA, Katherine J. BA, Jean Y. MD, PhD, Kavita Y. MD, PhD,