Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6070277 | Journal of the American Academy of Dermatology | 2015 | 10 Pages |
Abstract
In the past decade, the availability of powerful molecular techniques has accelerated the pace of discovery of several new primary immunodeficiencies (PIDs) and revealed the biologic basis of other established PIDs. These genetic advances, in turn, have facilitated more precise phenotyping of associated skin and systemic manifestations and provide a unique opportunity to better understand the complex human immunologic response. These continuing medical education articles will provide an update of recent advances in PIDs that may be encountered by dermatologists through their association with eczematous dermatitis, infectious, and non-infectious cutaneous manifestations. Part I will discuss new primary immunodeficiencies that have an eczematous dermatitis. Part II will focus on primary immunodeficiencies that greatly increase susceptibility to fungal infection and the noninfectious presentations of PIDs.
Keywords
VZVMolluscum contagiosum virusAD-HIESIPEXPGM3HIESDOCK8Tyk2MCVHSCTIDDMSTAT3MST1TregTLRMMPFOXP3CMCPIDBMDHSVnatural killerAutosomal DominantAutosomal recessiveEBVinterferonIFNinterleukinWASBone mineral densitytyrosine kinase 2Toll-like receptorInsulin-dependent diabetes mellitusWiskott–Aldrich syndromesignal transducer and activator of transcription 3MetalloproteinaseDedicator of cytokinesis 8Regulatory T Epstein–Barr virusherpes simplex virusVaricella zoster virusHuman papillomavirusHPVforkhead box protein 3Hematopoietic stem cell transplantchronic mucocutaneous candidiasisprimary immunodeficiency
Related Topics
Health Sciences
Medicine and Dentistry
Dermatology
Authors
Dominique C. MD, Alexandra F. MD, Edward W. MD, MHSc,