Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6071314 | Journal of the American Academy of Dermatology | 2014 | 10 Pages |
Abstract
Mucosal melanomas are aggressive cancers of mucosal surfaces with clinical and pathologic characteristics distinct from cutaneous melanomas, warranting different staging systems and treatment approaches. Surgical resection is performed frequently for the primary tumor, although the utility of lymph node surgery and radiation therapy is not established. Therapies targeted against C-KIT activating mutations, identified in many mucosal melanomas, are emerging as promising treatments.
Keywords
AJCCv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homologTNMSLNBMMUc-kitWLEMMPCSDDSSAprabdominoperineal resectiondisease-specific survivaloverall survivaltumor, node, metastasisTreatmentWide local excisionSEERCutaneous melanomaMucosal melanomaSurveillance, Epidemiology, and End ResultsSentinel lymph node biopsyClinical characteristicsPathologyoverall responseRadiation therapyAmerican Joint Committee on Cancer
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Authors
Joselin D. MD, Julie CNP, Yoon K. DO, Joshua MD, Julian MD, Henry B. MD, Kord MD, Kevin D. MD, Meg R. MD,