Secukinumab retreatment-as-needed versus fixed-interval maintenance regimen for moderate to severe plaque psoriasis: A randomized, double-blind, noninferiority trial (SCULPTURE)

Article ID	Journal	Published Year	Pages	File Type
6071433	Journal of the American Academy of Dermatology	2015	11 Pages	PDF

Abstract

Secukinumab fixed interval showed clear benefit versus the study-specified retreatment-as-needed regimen for maintaining efficacy. Both regimens exhibited safety consistent with previous trials. The potential of retreatment as needed with secukinumab warrants further investigation.

Keywords

PASI 100 QOL PASI 90 DLQI PASI 75 secukinumab Quality of life Investigator Global Assessment Immunogenicity IgA PASI Dosing Dermatology Life Quality Index adverse event Noninferiority Stature Sculpture psoriasis area and severity index Psoriasis Clinical trial

Related Topics

Health Sciences Medicine and Dentistry Dermatology

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Secukinumab retreatment-as-needed versus fixed-interval maintenance regimen for moderate to severe plaque psoriasis: A randomized, double-blind, noninferiority trial (SCULPTURE)

Authors

Ulrich MD, Craig L. MD, Giampiero MD, Darryl MD, FRCPC, Akimichi MD, Shyamal A. FCPS, Jacek C. MD, Pascaline PhD, Helen MSc, Charis MD, SCULPTURE Study Group SCULPTURE Study Group,