The activation of the NF-ÎºB-JNK pathway is independent of the PI3K-Rac1-JNK pathway involved in the bFGF-regulated human fibroblast cell migration

Article ID	Journal	Published Year	Pages	File Type
6074126	Journal of Dermatological Science	2016	28 Pages	PDF

Abstract

This study sheds light on the mode of action of bFGF and identifies that the NF-ÎºB-JNKs pathway is independent of the PI3K-JNKs pathway to accelerate fibroblast migration. In addition, bFGF and the relief of inflammation could be a favorable therapeutic approach for skin wound healing.

Keywords

IL8 PI3 K IκB-α Jun N-terminal kinase Ptgs2 PAI-1 chemokine (C-X-C motif) ligand 2 FGFR PKC GSK-3β ERK GAPDH bFGF RNA-seq Jnk NF-κB PBS DMEM ECM CXCL2 FBS DMSO MAPK Dulbecco’s modified Eagle medium Interleukin 8 Transcriptome RNA-sequencing Dimethyl sulfoxide fetal bovine serum basic fibroblast growth factor tumor necrosis factor TNF-α nuclear factor kappa B Phosphate buffered saline Phosphatidylinositol 3-kinase Extracellular matrix Cell migration Plasminogen activator inhibitor-1 Gene ontology extracellular regulated protein kinases Protein kinase C mitogen-activated protein kinase prostaglandin-endoperoxide synthase 2 glyceraldehyde-3-phosphate dehydrogenase Glycogen synthase kinase 3β fibroblast growth factor receptor