| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6074167 | Journal of Dermatological Science | 2015 | 9 Pages |
Abstract
Supplementation particularly with the PPARα agonist WY14643 improved the homeostasis and barrier function of filaggrin deficient skin models by normalization of the free fatty acid profile underlining the potential of PPAR agonists for the treatment of filaggrin-associated skin diseases.
Keywords
qPCRHPTLCFFAIVLPPARLORPPAR agonistsdocosahexaenoic acidFree fatty acidsAtopic dermatitisDHAFTIRFourier transform infrared spectroscopyStratum corneumLoricrinwild typereal-time quantitative polymerase chain reactionWestern blotSkin lipidshigh performance thin layer chromatographyinvolucrinperoxisome proliferator-activated receptor
Related Topics
Health Sciences
Medicine and Dentistry
Dermatology
Authors
Leonie Wallmeyer, Dominika Lehnen, Natascha Eger, Michaela Sochorová, LukáÅ¡ Opálka, Andrej KováÄik, KateÅina Vávrová, Sarah Hedtrich,