Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6074263 | Journal of Dermatological Science | 2014 | 13 Pages |
Abstract
Ligand-induced CYP1A1 and AhR degradation did not correlate with their chloracnegenic potential, indicating that neither CYP1A1 nor AhR are suitable biomarkers. Mechanistic studies showed that the TCDD-induced chloracne-like phenotype depends on AhR activation whereas AhR knock down did not appear sufficient to induce the phenotype.
Keywords
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Dermatology
Authors
Alison R. Forrester, Martina S. Elias, Emma L. Woodward, Mark Graham, Faith M. Williams, Nick J. Reynolds,