Nucleophagy: A New Look at Past Observations

Keratinization of the stratum corneum involves a highly choreographed sequence of events in which granular cells lose their nuclei and become desiccated corneocytes. Akinduro et al. detail the molecular machinery underlying removal of the nucleus (nucleophagy) during the final stages of keratinization. They provide evidence that nucleophagy is induced when the keratinocytes differentiate and that failure in the initiation of nucleophagy is associated with parakeratosis.