Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6074795 | Journal of Investigative Dermatology | 2016 | 9 Pages |
Abstract
In this study, we found that secreted frizzled-related protein 2 (sFRP2) is overexpressed in the hyperpigmentary skin of melasma and solar lentigo and in acutely UV-irradiated skin. To investigate the effect of sFRP2 on melanogenesis, normal human melanocytes were infected with sFRP2-lentivirus or sh-sFRP2. It was found that sFRP2 stimulates melanogenesis through microphthalmia-associated transcription factor and/or tyrosinase upregulation via β-catenin signaling. The stimulatory action of sFRP2 in pigmentation was further confirmed in melanocytes cocultured with fibroblasts and in ex vivo cultured skin. The findings suggest that sFRP2 functions as a melanogenic stimulator and that it plays a role in the development of UV-induced hyperpigmentary disorders.
Keywords
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Dermatology
Authors
Misun Kim, Jae Ho Han, Jang-Hee Kim, Tae Jun Park, Hee Young Kang,