| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6075092 | Journal of Investigative Dermatology | 2015 | 5 Pages |
Abstract
Human and mouse skin accumulate senescent cells in both the epidermis and dermis during aging. When chronically present, senescent cells are thought to enhance the age-dependent deterioration of the skin during extrinsic and intrinsic aging. However, when transiently present, senescent cells promote optimal wound healing. Here, we review recent studies on how senescent cells and the senescence-associated secretory phenotype contribute to different physiological and pathophysiological conditions in the skin with a focus on some of the cell autonomous and non-autonomous functions of senescent cells in the context of skin aging and wound healing.
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Authors
Marco Demaria, Pierre Yves Desprez, Judith Campisi, Michael C. Velarde,