Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6075275 | Journal of Investigative Dermatology | 2016 | 7 Pages |
Abstract
Psoriasis is a chronic inflammatory skin condition resulting from a complex interplay among the immune system, keratinocytes, susceptibility genes, and environmental factors. However, the pathogenesis of psoriasis is not completely elucidated. microRNAs represent a promising class of small, noncoding RNA molecules that function to regulate gene expression. Although microRNA research in psoriasis and dermatology is still relatively new, evidence is rapidly accumulating for the role of microRNAs in the pathogenesis of psoriasis and other chronic inflammatory conditions. In this article, we present a comprehensive review of what is known about microRNAs and their role in the pathogenesis of psoriasis.
Keywords
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Authors
Jason E. Hawkes, Giang Huong Nguyen, Mayumi Fujita, Scott R. Florell, Kristina Callis Duffin, Gerald G. Krueger, Ryan M. O'Connell,