| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6077055 | Journal of Investigative Dermatology | 2013 | 5 Pages |
Abstract
In this issue, Takekoshi et al. investigated the role of CXCR4 in IL-23-induced keratinocyte hyperproliferation using an epidermal-specific knockout mouse model and found that CXCR4 limited keratinocyte proliferation. Some reports in the literature support this idea, whereas others contradict it; this disparity may be related to the differential roles of CXCR4 in various cell types or to a recently identified second receptor (CXCR7). Nevertheless, CXCR4 and its ligand SDF-1 have been implicated in skin wound healing, systemic lupus erythematosus, and basal cell carcinoma tumor angiogenesis. Further study is merited.
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Authors
Wendy B. Bollag, William D. Hill,