| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6078330 | Journal of Investigative Dermatology | 2011 | 4 Pages |
Abstract
Exposure of cells and human skin to UVA radiation oxidatively induces damage to DNA that consists mostly of 8-oxo-7,8-dihydroguanine (8-oxoGua), together with relatively minor amounts of oxidized pyrimidine bases and oligonucleotide strand breaks. Singlet oxygen generated by the type II photosensitization mechanism forms 8-oxoGua, with a small contribution by hydroxyl radicals. The mechanisms of UVA-mediated formation of DNA oxidation products indicate the absence of induction of double-strand breaks.
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Authors
Jean Cadet, Thierry Douki,