Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6087601 | Clinical Immunology | 2013 | 12 Pages |
â¢TSPAN33 is a biomarker for activated B cells.â¢TSPAN33 is expressed in certain Lymphomas.â¢TSPAN33 is expressed in some autoimmune diseases (SLE and RA).â¢TSPAN33 is a potential diagnostic and therapeutic target of malignant B cells.
We have identified Tspan33 as a gene encoding a transmembrane protein exhibiting a restricted expression pattern including expression in activated B cells. TSPAN33 is a member of the tetraspanin family. TSPAN33 is not expressed in resting B cells, but is strongly induced in primary human B cells following activation. Human 2E2 cells, a Burkitt's lymphoma-derived B cell model of activation and differentiation, also upregulate TSPAN33 upon activation. TSPAN33 is expressed in several lymphomas including Hodgkin's and Diffuse large B cell lymphoma. TSPAN33 is also expressed in some autoimmune diseases where B cells participate in the pathology, including rheumatoid arthritis patients, systemic lupus erythematosus (SLE), and in spleen B cells from MRL/Faslpr/lpr mice (a mouse model of SLE). We conclude that TSPAN33 may be used as a diagnostic biomarker or as a target for therapeutic antibodies for treatment of certain B cell lymphomas or autoimmune diseases.