Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6088737 | Digestive and Liver Disease | 2013 | 7 Pages |
BackgroundVillous elements and dysplasia grade in small adenomas are used in many countries to guide post-polypectomy colonoscopy intervals.AimsMeasure agreement in interpretation of villous elements and dysplasia in small adenomas.MethodsConsecutive endoscopically resected adenomas <10Â mm in size (203 adenomas less than 6Â mm and 149 adenomas 6-9Â mm in size) were reviewed by 3 expert gastrointestinal pathologists. Interpretations were compared to routine clinical pathology readings at our institution and to each other.ResultsAll pathologists used the same definitions for villous and tubular histology. The overall kappas for villous elements in <6Â mm and 6-9Â mm adenomas were 0.29 and 0.26, respectively. Interpretation of dysplasia grade had kappas of 0.02 and 0.09 for adenomas <6Â mm and 6-9Â mm, respectively. Two expert pathologists who used cytologic criteria had much higher fractions of high grade dysplasia compared to the third expert and the pathologists at our centre, who relied on architectural criteria.ConclusionsVillous elements and dysplasia grade in small adenomas are problematic as determinants of post-polypectomy surveillance intervals. Uniform pathologic criteria for dysplasia grade are needed.