| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6088803 | Digestive and Liver Disease | 2014 | 6 Pages |
BackgroundBarrett's oesophagus is a premalignant condition, predisposing to oesophageal adenocarcinoma. However, some adenocarcinoma may arise in columnar lined oesophagus without goblet cells. Our aim was to evaluate the biological properties of non-goblet columnar lined oesophagus only and elucidate its relationship with Barrett's oesophagus and associated neoplasia.MethodsEndoscopic biopsies from patients with Barrett's oesophagus (n = 30), non-goblet columnar lined oesophagus (n = 14), Barrett's oesophagus associated high grade dysplasia (n = 6) and adenocarcinoma (n = 4) were selected. Immunostaining for villin, claudin 3 and MUC4 was performed. Statistical analysis was performed and a p value <0.05 was considered significant.ResultsVillin and MUC4 were positive in 42%, 100% each and 50% in non-goblet columnar lined oesophagus, Barrett's oesophagus, high grade dysplasia and adenocarcinoma respectively, while claudin 3 was 100% positive in all the groups. In non-goblet columnar lined oesophagus, six cases that were villin immunopositive, showed positive expression for claudin 3 and/or MUC4 and there was no difference from the high grade dysplasia or adenocarcinoma (p > 0.05).ConclusionOur results indicate that a subset of non-goblet columnar lined oesophagus shows an intestinal phenotype representing an early stage of Barrett's oesophagus. This subset probably harbours the potential to change into adenocarcinoma in the long term.
