Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6090643 | Nutrition | 2008 | 7 Pages |
Abstract
Our results show that active immunization of rats against the MC4R resulted in the generation of specific Abs that stimulated food intake by acting as inverse agonists of the hypothalamic MC4R. Pharmacologically active monoclonal MC4R Abs could be the starting point for the development of novel treatments for patients with anorexia or cachexia.
Keywords
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Authors
Karl G. M.D., Anne-Catherine M.S., Jean-Christophe Ph.D.,