Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6091477 | Clinical Gastroenterology and Hepatology | 2014 | 8 Pages |
Abstract
In a multicenter prospective study of treatment-naive patients with chronic hepatitis B, we detected mutations in HBV DNA polymerase in only 1%. Because of the low prevalence of these mutations and the uncertain clinical significance of such quasispecies, routine HBV DNA polymerase mutation analysis cannot be recommended before initiation of antiviral therapy for treatment-naive patients with chronic hepatitis B. The analysis requires further molecular and clinical studies.
Keywords
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Authors
Philip Vutien, Huy N. Trinh, Ruel T. Garcia, Huy A. Nguyen, Brian S. Levitt, Khanh Nguyen, Eduardo da Silveira, Tami Daugherty, Aijaz Ahmed, Gabriel Garcia, Glen A. Lutchman, Mindie H. Nguyen,