| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6092098 | Gastroenterology | 2016 | 51 Pages |
Abstract
Peptide inhibitors of CD44v6 isoforms block tumor growth and metastasis in several independent models of pancreatic cancer. The v6 peptides induced regression of metastases. Levels of CD44v6 mRNA are increased, along with those of MET mRNA, in patients with metastatic pancreatic tumors, compared with nonmetastatic tumors; the increased levels correlated with shorter patient survival time.
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Authors
Alexandra Matzke-Ogi, Katharina Jannasch, Marine Shatirishvili, Beatrix Fuchs, Sara Chiblak, Jennifer Morton, Bouchra Tawk, Thomas Lindner, Owen Sansom, Frauke Alves, Arne Warth, Christian Schwager, Walter Mier, Jörg Kleeff, Helmut Ponta,