| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6092212 | Gastroenterology | 2015 | 48 Pages |
Abstract
Interleukin-6 up-regulates STAT3-mediated transcription of miR214 in colon tissues, which reduces levels of PDLIM2 and PTEN, increases phosphorylation of AKT, and activates nuclear factor-κB. The activity of this circuit correlates with disease activity in patients with UC and progression to colorectal cancer.
Keywords
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Authors
Christos Polytarchou, Daniel W. Hommes, Tiziana Palumbo, Maria Hatziapostolou, Marina Koutsioumpa, Georgios Koukos, Andrea E. van der Meulen-de Jong, Angelos Oikonomopoulos, Welmoed K. van Deen, Christina Vorvis, Oksana B. Serebrennikova, Eleni Birli,