| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6092222 | Gastroenterology | 2015 | 53 Pages |
Abstract
In mice, chronic-plus-binge ethanol feeding induces ASH that mimics some histological and molecular features observed in patients with AH. Hepatic expression of FSP27/CIDEC is highly up-regulated in mice following chronic-plus-binge ethanol feeding and in patients with AH; this up-regulation contributes to alcohol-induced liver damage.
Keywords
ABICFsp27CREBHPPARγGRP78HVPGBiPMPOROSALDalcoholic steatohepatitisinflammationalcoholic liver diseaseCHOPAshendoplasmic reticulumHepatic venous pressure gradientLipid metabolismmyeloperoxidaseAlcoholic hepatitis78-kDa glucose-regulated proteinfat-specific protein 27Translational researchReactive oxygen speciesperoxisome proliferator-activated receptor γ
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Authors
Ming-Jiang Xu, Yan Cai, Hua Wang, José Altamirano, Binxia Chang, Adeline Bertola, Gemma Odena, Jim Lu, Naoki Tanaka, Kimihiko Matsusue, Tsutomu Matsubara, Partha Mukhopadhyay, Shioko Kimura, Pal Pacher, Frank J. Gonzalez, Ramon Bataller, Bin Gao,