| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6092224 | Gastroenterology | 2015 | 39 Pages |
Abstract
We identified a GPC3367-specific T-cell receptor. Expression of this receptor by T cells allows them to recognize and kill GPC3-positive hepatoma cells. This finding could be used to advance development of adoptive T-cell therapy for HCC.
Keywords
IVTGlypican-3MoDCLCLGPC3TCrLAMP1PBMCTAAeffector to target cell ratioMonocyte-derived DCE:THCCHuman leukocyte antigentumor-associated antigentumor-associated antigensHLACancer immunotherapyinterferonIFNinterleukinIn vitroLiver cancerPeripheral blood mononuclear cellLymphoblastoid cell linemajor histocompatibility complexMHCImmune responseLysosomal-associated membrane protein 1Hepatocellular carcinomaT-cell receptor
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Authors
Christina Dargel, Michal Bassani-Sternberg, Julia Hasreiter, Fabio Zani, Jan-Hendrik Bockmann, Frank Thiele, Felix Bohne, Karin Wisskirchen, Susanne Wilde, Martin F. Sprinzl, Dolores J. Schendel, Angela M. Krackhardt, Wolfgang Uckert, Dirk Wohlleber,