Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6092374 | Gastroenterology | 2015 | 45 Pages |
Abstract
LPCAT3 KO mice have longer and larger small intestines than control mice, with shorter wide villi, reduced lipid absorption, and lower levels NPC1L1, CD36, and FATP4 proteins. Inhibition of LPCAT3 in the small intestine could be developed as an approach to treat hyperlipidemia.
Keywords
mRNAFATP4Niemann-Pick C1-like 1NPC1L1LPCATLXRVLDLMTPBLPPPARHDLhigh-density lipoproteinLC/MS/MSmessenger RNAPPREPolyunsaturated fatty acidPUFAendoplasmic reticulumphosphatidylcholinelysophosphatidylcholine acyltransferasevery-low-density lipoproteinMouse modelLipid regulationknockoutwild typemicrosomal triglyceride transfer proteinfatty acid transport protein 4liver X receptorLiquid chromatography with tandem mass spectrometryperoxisome proliferator-activated receptor
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Authors
Zhiqiang Li, Hui Jiang, Tingbo Ding, Caixia Lou, Hai H. Bui, Ming-Shang Kuo, Xian-Cheng Jiang,