| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6092487 | Gastroenterology | 2016 | 66 Pages |
Abstract
Undifferentiated or crypt-like, and differentiated or villus-like, human enteroids represent distinct points along the crypt-villus axis; they can be used to characterize electrolyte transport processes along the vertical axis of the small intestine. The duodenal enteroid model showed that electrogenic Na+/HCO3- cotransporter 1 might be a target in the intestinal mucosa for treatment of secretory diarrheas.
Keywords
DIDSNa+ AbsorptionNa+/H+ exchanger 3NHE3NBCe1Intestinal organoidsEIPANKCC1CFTRpKacGMPmRNAPHIFIScAMPDRAIntracellular pHmessenger RNACyclic adenosine monophosphatedifferentiation mediumcystic fibrosis transmembrane conductance regulatorexpansion mediumcyclic guanosine monophosphatedown-regulated in adenomaprotein kinase A
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Authors
Jennifer Foulke-Abel, Julie In, Jianyi Yin, Nicholas C. Zachos, Olga Kovbasnjuk, Mary K. Estes, Hugo de Jonge, Mark Donowitz,