| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6092502 | Gastroenterology | 2016 | 34 Pages |
Abstract
Epithelial TGFβ signaling does not contribute to the development of liver fibrosis or formation of hepatocellular carcinomas in mice, but restricts cholangiocyte proliferation to prevent cholangiocarcinoma development, regardless of its cellular origin.
Keywords
BDLTGFβ-activated kinase 1phosphorylated SmadpSmadTAK1Tbr2DenTGFβmRNAα-SMAHSCqPCRddCHCCmessenger RNAα-smooth muscle actinTransforming growth factor βdiethylnitrosamineLiver cancerHepatic stellate cellMouse modelSignal transductionquantitative real-time polymerase chain reactionbile duct ligationHepatocellular carcinoma
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Authors
Xueru Mu, Jean-Philippe Pradere, Silvia Affò, Dianne H. Dapito, Richard Friedman, Jay H. Lefkovitch, Robert F. Schwabe,