| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6092585 | Gastroenterology | 2016 | 35 Pages |
Abstract
We provide evidence for an association between the MBOAT7 rs641738 variant and the development and severity of NAFLD in individuals of European descent. This association seems to be mediated by changes in the hepatic phosphatidylinositol acyl-chain remodeling.
Keywords
IFGMBOAT7NAFLDtransmembrane 6 superfamily member 2TM6SF2Dallas heart studypatatin-like phospholipase domain-containing 3PNPLA3T2DMmRNADHSHWEmessenger RNAImpaired fasting glucosenonalcoholic steatohepatitisArachidonic acidNonalcoholic fatty liver diseaseHardy-Weinberg equilibriumType 2 diabetes mellitusbody mass indexBMIendoplasmic reticulumconfidence intervalphosphatidylinositolodds ratioNash
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Authors
Rosellina Margherita Mancina, Paola Dongiovanni, Salvatore Petta, Piero Pingitore, Marica Meroni, Raffaela Rametta, Jan Borén, Tiziana Montalcini, Arturo Pujia, Olov Wiklund, George Hindy, Rocco Spagnuolo, Benedetta Maria Motta, Rosaria Maria Pipitone,