| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6092698 | Gastroenterology | 2015 | 48 Pages |
Abstract
VAT and SAT from patients with NAFLD and NASH have an increased expression of genes that regulate inflammation, and ATM produce increased levels of inflammatory cytokines, compared with adipose tissues from controls. We identified an expression profile of 5 genes in SAT that accurately predict liver histology in these patients. Transcript profiling: accession numbers: GSE58979 and GSE59045.
Keywords
NASNAFLDTNFPNPLA3AUROCCCLIL8ALTqRT-PCRSATCCRC-C chemokine receptorcDNAComplementary DNAASTAspartate aminotransferaseAlanine aminotransferasenonalcoholic steatohepatitisinterleukinAdipose tissuevisceral adipose tissueSubcutaneous adipose tissueGene expressionNonalcoholic fatty liver diseaseATMbody mass indexBMItumor necrosis factorchemokine (C-C motif) ligandVATAdipose tissue macrophageImmune regulationarea under receiver operating characteristicNonalcoholic fatty liver disease activity scoreNash Inflammatory responsequantitative reverse transcription polymerase chain reactionpatatin-like phospholipase domain-containing protein 3
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Authors
Johannie du Plessis, Jos van Pelt, Hannelie Korf, Chantal Mathieu, Bart van der Schueren, Matthias Lannoo, Tom Oyen, Baki Topal, Gary Fetter, Simon Nayler, Tessa van der Merwe, Petra Windmolders, Luc Van Gaal, An Verrijken, Guy Hubens, Martin Gericke,