Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6092716 | Gastroenterology | 2015 | 51 Pages |
Abstract
In mice with humanized livers, expression of an FGF19 transgene corrects bile acid signaling defects, resulting in normalization of bile acid synthesis, the bile acid pool, and liver size. These findings indicate that liver size is, in part, regulated by the size of the bile acid pool that the liver must circulate.
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Authors
Willscott E. Naugler, Branden D. Tarlow, Lev M. Fedorov, Matthew Taylor, Carl Pelz, Bin Li, Jennifer Darnell, Markus Grompe,