| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6092720 | Gastroenterology | 2015 | 61 Pages |
Abstract
Increased expression of GP73 promotes proliferation and migration of HCC cell lines and growth of xenograft tumors in mice. mTORC1 regulates the expression of GP73, so GP73 up-regulation can be blocked with rapamycin. mTOR inhibitors or other reagents that reduce the level or activity of GP73 might be developed for the treatment of HCC.
Keywords
PI3Kmechanistic target of rapamycin complexGP73mTORCDenTSCmTORshRNAMMPMEFHCCSmall interfering RNAsiRNADrugdiethylnitrosamineLiver cancerphosphatase and tensin homologphosphatidylinositol-3 kinasematrix metalloproteinaseMouse modelmouse embryonic fibroblastSignal transductionMechanistic target of rapamycinHBVHCVHepatitis C virushepatitis B virusGolgi protein 73PtenHepatocellular carcinomaTuberous sclerosis complex
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Authors
Xinxin Chen, Yanan Wang, Jun Tao, Yuzhuo Shi, Xiaochen Gai, Fuqiang Huang, Qian Ma, Zhenzhen Zhou, Hongyu Chen, Haihong Zhang, Zhibo Liu, Qian Sun, Haiyong Peng, Rongrong Chen, Yanling Jing, Huayu Yang, Yilei Mao, Hongbing Zhang,