| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6092915 | Gastroenterology | 2016 | 23 Pages |
Abstract
Loss of ACVR1B accelerates growth of mutant KRAS-induced pancreatic IPMNs in mice; this process appears to involve NOTCH4 and loss of p16. ACVR1B suppresses early stages of pancreatic tumorigenesis; the activin signaling pathway therefore might be a therapeutic target for pancreatic cancer.
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Authors
Wanglong Qiu, Sophia M. Tang, Sohyae Lee, Andrew T. Turk, Anthony N. Sireci, Anne Qiu, Christian Rose, Chuangao Xie, Jan Kitajewski, Hui-Ju Wen, Howard C. Crawford, Peter A. Sims, Ralph H. Hruban, Helen E. Remotti, Gloria H. Su,