Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6093192 | Gastroenterology | 2015 | 36 Pages |
Abstract
Levels of SIGIRR are lower in human colorectal tumors, compared with nontumor tissues; tumors contain the dominant-negative isoform SIGIRRÎE8. This mutant protein blocks localization of full-length SIGIRR to the surface of colon epithelial cells and its ability to downregulate IL1R signaling. Expression of SIGIRRN86/102S in the colonic epithelium of mice increases expression of inflammatory cytokines and formation and size of colitis-associated tumors.
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Authors
Junjie Zhao, Katarzyna Bulek, Muhammet F. Gulen, Jarod A. Zepp, Georgio Karagkounis, Bradley N. Martin, Hao Zhou, Minjia Yu, Xiuli Liu, Emina Huang, Paul L. Fox, Matthew F. Kalady, Sanford D. Markowitz, Xiaoxia Li,