Article ID Journal Published Year Pages File Type
6093192 Gastroenterology 2015 36 Pages PDF
Abstract
Levels of SIGIRR are lower in human colorectal tumors, compared with nontumor tissues; tumors contain the dominant-negative isoform SIGIRRΔE8. This mutant protein blocks localization of full-length SIGIRR to the surface of colon epithelial cells and its ability to downregulate IL1R signaling. Expression of SIGIRRN86/102S in the colonic epithelium of mice increases expression of inflammatory cytokines and formation and size of colitis-associated tumors.
Related Topics
Health Sciences Medicine and Dentistry Gastroenterology
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