| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6093198 | Gastroenterology | 2015 | 36 Pages |
Abstract
PGE2 induces CSC expansion by activating NF-κB, via EP4-PI3K and EP4-mitogen-activated protein kinase signaling, and promotes the formation of liver metastases in mice. The PGE2 signaling pathway therefore might be targeted therapeutically to slow CSC expansion and colorectal cancer progression.
Keywords
CSCEpCAMERK1PGE2shRNANSAIDNSGPI3KNSAIDSNF-κBMAPKshort hairpin RNAcyclooxygenaseAktIHCimmunohistochemicalTumorigenesisnonsteroidal anti-inflammatory drugColorectal cancerColon cancernuclear factor-κBphosphoinositide 3-kinasepolymerase chain reactionPCRprotein kinase Bmitogen-activated protein kinaseProstaglandin E2CRC
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Authors
Dingzhi Wang, Lingchen Fu, Haiyan Sun, Lixia Guo, Raymond N. DuBois,