| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6093210 | Gastroenterology | 2015 | 52 Pages |
Abstract
Targeted inhibition of STAT3 combined with gemcitabine enhances in vivo drug delivery and therapeutic response in PDAC. These effects occur through tumor stromal remodeling and down-regulation of cytidine deaminase without depletion of tumor stromal content.
Keywords
GEMMphosphorylated signal transducer and activator of transcriptionsHGpStatCDATMETMAPancreatic ductal adenocarcinomaPDAC یا pancreatic ductal adenocarcinomaSTATStromaMRIMagnetization transferoverall survivalDrug deliveryMagnetic resonance imagingSecond harmonic generationmatrix-assisted laser desorption/ionizationPancreatic cancercytidine deaminaseMALDISignal transducer and activator of transcriptiongenetically engineered mouse modelshort hairpin Tumor microenvironmentTissue microarray
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Authors
Nagaraj S. Nagathihalli, Jason A. Castellanos, Chanjuan Shi, Yugandhar Beesetty, Michelle L. Reyzer, Richard Caprioli, Xi Chen, Alex J. Walsh, Melissa C. Skala, Harold L. Moses, Nipun B. Merchant,