| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6093358 | Gastroenterology | 2015 | 43 Pages |
Abstract
Colon tissues from patients with IBS have increased levels of specific PUFA metabolites. These stimulate sensory neurons from mice and generate visceral hypersensitivity via activation of TRPV4.
Keywords
COXIBS-MVMRTransient receptor potential ankyrin-1IBS-DIBS-CPAR2TRPVCRDIBSPGE2PGATRPA1TrpDRGSmall interfering RNAsiRNAcyclooxygenasecolorectal distensionArachidonic acidepoxyeicosatrienoic acidhydroxyeicosatetraenoic acidPolyunsaturated fatty acidPUFALOXEETPainFast Blueirritable bowel syndromeProteolytic activitylipoxygenaseHETEtransient receptor potential vanilloidtransient receptor potentialProteaseProstaglandin E2healthy controldorsal root gangliaproteinase-activated receptor 2
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Authors
Nicolas Cenac, Tereza Bautzova, Pauline Le Faouder, Nicholas A. Veldhuis, Daniel P. Poole, Corinne Rolland, Jessica Bertrand, Wolfgang Liedtke, Marc Dubourdeau, Justine Bertrand-Michel, Lisa Zecchi, Vincenzo Stanghellini, Nigel W. Bunnett,