| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6093367 | Gastroenterology | 2015 | 50 Pages |
Abstract
NOX4 regulates oxidative stress in the liver and its levels are increased in patients with NASH and mice with diet-induced steatohepatitis. Inhibitors of NOX4 reduce liver inflammation and fibrosis and increase insulin sensitivity, and might be developed for treatment of NASH.
Keywords
HSCdouble-stranded RNA-activated protein kinaseCSAATGF-βc-Jun-N-terminal kinaseCDAAPKRIRSJnkFFDNOxROSnonalcoholic steatohepatitisinflammationinsulin receptor substratetransforming growth factor-βtumor necrosis factor-αCHOPHepatic stellate cellStress signalingTNF-αMouse modelObesityNash CCAAT/enhancer-binding protein homologous proteinPERKReactive oxidative speciesinsulin receptor
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Authors
Ahmed Bettaieb, Joy X. Jiang, Yu Sasaki, Tzu-I Chao, Zsofia Kiss, Xiangling Chen, Jijing Tian, Masato Katsuyama, Chihiro Yabe-Nishimura, Yannan Xi, Cedric Szyndralewiez, Kathrin Schröder, Ajay Shah, Ralph P. Brandes, Fawaz G. Haj, Natalie J. Török,