| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6093478 | Gastroenterology | 2015 | 23 Pages |
Abstract
Some patients with CIPO carry mutations in RAD21 that disrupt the ability of its product to regulate genes such as RUNX1 and APOB. Reduced expression of rad21 in zebrafish, and dysregulation of these target genes, disrupts intestinal transit and the development of enteric neurons.
Keywords
DPFmRNART-PCRIBSLCLapoBcDNAComplementary DNAmessenger RNAApolipoprotein Birritable bowel diseaseGenetic analysisIntestinal motilitydays postfertilizationLymphoblastoid cell lineChronic intestinal pseudo-obstructionAnimal modelmorpholinoCIPOreverse-transcription polymerase chain reactionSingle-nucleotide polymorphismSNP
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Authors
Elena Bonora, Francesca Bianco, Lina Cordeddu, Michael Bamshad, Ludmila Francescatto, Dustin Dowless, Vincenzo Stanghellini, Rosanna F. Cogliandro, Greger Lindberg, Zeynel Mungan, Kivanc Cefle, Tayfun Ozcelik, Sukru Palanduz, Sukru Ozturk,