| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6093486 | Gastroenterology | 2015 | 75 Pages |
Abstract
In a genomic analysis of 78 FLC samples, we identified 3 classes based on gene expression profiles. FLCs contain mutations and chromosomal aberrations not previously associated with liver cancer, and almost 80% contain the DNAJB1âPRKACA fusion transcript. By using this information, we identified a gene signature that is associated with patient survival time.
Keywords
EGFRFLCTSGEpCAMWESGSEAIPAmTORTESICCNGSCNVFDRHCCFFPEIHCImmunohistochemistryinterleukinIngenuity Pathway AnalysisGene-set enrichment analysisNext-generation sequencingWhole-exome sequencingTargeted therapiesMortality indexMolecular classificationconfidence intervalformalin-fixed paraffin-embeddedfalse discovery rateOutcomehazard ratiomammalian target of rapamycinGenomic profilingSingle-nucleotide polymorphismSNPtumor-suppressor geneFibrolamellar hepatocellular carcinomaHepatocellular carcinomaIntrahepatic cholangiocarcinomaCopy number variationsEpidermal growth factor receptor
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Authors
Helena Cornella, Clara Alsinet, Sergi Sayols, Zhongyang Zhang, Ke Hao, Laia Cabellos, Yujin Hoshida, Augusto Villanueva, Swan Thung, Stephen C. Ward, Leonardo Rodriguez-Carunchio, Maria Vila-Casadesús, Sandrine Imbeaud, Anja Lachenmayer,