| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6093592 | Gastroenterology | 2015 | 2460 Pages |
Abstract
CAP-D3 down-regulates transcription of genes that encode amino acid transporters (SLC7A5 and SLC3A2) to promote bacterial autophagy by colon epithelial cells. Levels of CAP-D3 protein are reduced in patients with active UC; strategies to increase its levels might restore mucosal homeostasis to patients with active UC.
Keywords
LEL2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acidLate endosome/lysosomeSCVAIECBCHLC3IBDqRT-PCRmTORshRNAmRNAmessenger RNAsmall hairpin RNAAdherent-invasive Escherichia coliInnate immunityInflammatory bowel diseaseDysbiosismicrotubule-associated protein light chain 3condensinmammalian target of rapamycinSalmonella-containing vacuolequantitative reverse transcription polymerase chain reactionUlcerative colitis
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Authors
Andrew T. Schuster, Craig R. Homer, Jacqueline R. Kemp, Kourtney P. Nickerson, Emily Deutschman, Yeojung Kim, Gail West, Tammy Sadler, Eleni Stylianou, Dawid Krokowski, Maria Hatzoglou, Carol de la Motte, Brian P. Rubin, Claudio Fiocchi,