Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6093594 | Gastroenterology | 2015 | 19 Pages |
Abstract
TGFβ signaling remains active in some MSI-H CRC cells despite the presence of frameshift mutations in the TGFBR2 gene because the mutated gene still expresses a functional protein. Strategies to reactivate TGFβ signaling in colorectal tumors might not be warranted, and the functional effects of mutations at other regions of microsatellite instability should be evaluated.
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Authors
Noel F.C.C. de Miranda, Maarten van Dinther, Brendy E.W.M. van den Akker, Tom van Wezel, Peter ten Dijke, Hans Morreau,