Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6093599 | Gastroenterology | 2015 | 22 Pages |
Abstract
VEGFC signaling via VEGFR3 promotes lymphangiogenesis and metastasis by orthotopic colorectal tumors in mice and reduces lymphatic endothelial barrier integrity. Levels of VEGFC and markers of lymphatic vessels are increased in CRC tissues from patients, compared with healthy intestine. Strategies to block VEGFR3 might be developed to prevent CRC metastasis in patients.
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Authors
Carlotta Tacconi, Carmen Correale, Alessandro Gandelli, Antonino Spinelli, Elisabetta Dejana, Silvia D'Alessio, Silvio Danese,