| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6093754 | Gastroenterology | 2014 | 11 Pages |
Abstract
Intestinal SIRT1, a key nutrient sensor, is required for ileal bile acid absorption and systemic bile acid homeostasis in mice. We delineated the mechanism of metabolic regulation of HNF-1α/FXR signaling. Reagents designed to inhibit intestinal SIRT1 might be developed to treat bile acid-related diseases such as cholestasis.
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Authors
Nevzat Kazgan, Mallikarjuna R. Metukuri, Aparna Purushotham, Jing Lu, Anuradha Rao, Sangkyu Lee, Matthew Pratt-Hyatt, Andrew Lickteig, Iván L. Csanaky, Yingming Zhao, Paul A. Dawson, Xiaoling Li,