| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6093756 | Gastroenterology | 2014 | 11 Pages |
Abstract
We observed that in mice given food antigen, cooperation between IL15 and CD4+ T cells is necessary and sufficient to activate CD8+ T cells and damage the small intestine. We propose that this process is involved in the development of celiac disease.
Keywords
PBSmAbrhILIELnTregTCrMLNiTregTregOVAMonoclonal antibodyinterferonIFNinterleukinrecombinant human interleukinCeliac diseaseRegulatory T cellDendritic cellTreg cellsLamina propriaT lymphocyteIntraepithelial lymphocytePhosphate-buffered salineMouse modelImmune regulationwild typemesenteric lymph nodesT-cell receptor
Related Topics
Health Sciences
Medicine and Dentistry
Gastroenterology
Authors
Natalia Korneychuk, Emma Ramiro-Puig, Julien Ettersperger, Julie Schulthess, Nicolas Montcuquet, Hiroshi Kiyono, Bertrand Meresse, Nadine Cerf-Bensussan,