Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6093772 | Gastroenterology | 2014 | 20 Pages |
Abstract
Human NTCP is a specific receptor for HBV and HDV. NTCP-expressing cell lines can be efficiently infected with these viruses, and might be used in basic research and high-throughput screening studies. Mapping of motifs in NTCPs have increased our understanding of the species specificities of HBV and HDV, and could lead to small animal models for studies of viral infection and replication.
Keywords
PHHcccDNAHDVHBsAgNtcpHBeAgHBcAgshRNAPBSDMSOcovalently closed circular DNAprimary human hepatocytesmall hairpin RNAHepatitis B surface antigenHumanDimethyl sulfoxidePhosphate-buffered salineSpecies specificityMouseHepatitis B e antigenhepatitis B core antigenHBVpolymerase chain reactionPCRVirus entryvirologyHepatitis D virushepatitis B virus
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Authors
Yi Ni, Florian A. Lempp, Stefan Mehrle, Shirin Nkongolo, Christina Kaufman, Maria Fälth, Jan Stindt, Christian Königer, Michael Nassal, Ralf Kubitz, Holger Sültmann, Stephan Urban,