| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6093780 | Gastroenterology | 2014 | 23 Pages |
Abstract
The TIC marker CD44s is up-regulated in human pancreatic tumors and associated with patient survival time. CD44s is required for initiation, growth, metastasis, and postradiation recurrence of xenograft tumors in mice. Anti-CD44s eliminated bulk tumor cells as well as TICs from the tumors. Strategies to target CD44s cab be developed to block pancreatic tumor formation and post-radiotherapy recurrence in patients.
Keywords
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Gastroenterology
Authors
Ling Li, Xinbao Hao, Jun Qin, Wenhua Tang, Fengtian He, Amber Smith, Min Zhang, Diane M. Simeone, Xiaotan T. Qiao, Zhi-Nan Chen, Theodore S. Lawrence, Liang Xu,