| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6093884 | Gastroenterology | 2015 | 46 Pages |
Abstract
Alisporivir inhibition of cyclophilins in hepatocyte cell lines reduces replication of HBV DNA and HBsAg production and secretion. These effects are potentiated in combination with direct antiviral agents that target HBV-DNA polymerase.
Keywords
FCSDMEMHBsAgAlisporivirCyPmRNADMSODulbecco’s modified Eagle mediummessenger RNASmall interfering RNAsiRNAHepatitis B surface antigenEnzyme-linked immunosorbent assayELISAViral replicationbaselineDimethyl sulfoxidefetal calf serumcyclophilindirect-acting antiviral agentlactate dehydrogenaseLDHAlvKnockdownHBVHepatitis C virusHCVpolymerase chain reactionPCRhepatitis B virusPeptidyl-prolyl isomerase
Related Topics
Health Sciences
Medicine and Dentistry
Gastroenterology
Authors
Sandra Phillips, Shilpa Chokshi, Udayan Chatterji, Antonio Riva, Michael Bobardt, Roger Williams, Philippe Gallay, Nikolai V. Naoumov,