Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6094018 | Gastroenterology | 2014 | 60 Pages |
Abstract
Neoplastic and non-neoplastic Barrett's epithelial cells have autocrine VEGF signaling. In neoplastic Barrett's cells, VEGF activation of VEGFR2 initiates a PLCG1âprotein kinase CâERK pathway that promotes proliferation and is self-sustaining (by causing more VEGF production). Strategies to reduce autocrine VEGF signaling (eg, with sunitinib) might be used to prevent or treat cancer in patients with Barrett's esophagus.
Keywords
rhVEGFmRNAshRNAVEGFRERKPKCPLCmessenger RNASmall interfering RNAshort-hairpin RNAsiRNABrdUbromodeoxyuridineApoptosisEsophageal cancerVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)phospholipase Cphospholipase Cγ1Mouse modelProtein kinase Cextracellular signal-regulated kinasevascular endothelial growth factor receptorvascular endothelial growth factor receptor 2
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Authors
Qiuyang Zhang, Chunhua Yu, Sui Peng, Hao Xu, Ellen Wright, Xi Zhang, Xiaofang Huo, Edaire Cheng, Thai H. Pham, Kiyotaka Asanuma, Kimmo J. Hatanpaa, Davood Rezai, David H. Wang, Venetia Sarode, Shelby Melton, Robert M. Genta, Stuart J. Spechler,