Article ID Journal Published Year Pages File Type
6094018 Gastroenterology 2014 60 Pages PDF
Abstract
Neoplastic and non-neoplastic Barrett's epithelial cells have autocrine VEGF signaling. In neoplastic Barrett's cells, VEGF activation of VEGFR2 initiates a PLCG1−protein kinase C−ERK pathway that promotes proliferation and is self-sustaining (by causing more VEGF production). Strategies to reduce autocrine VEGF signaling (eg, with sunitinib) might be used to prevent or treat cancer in patients with Barrett's esophagus.
Related Topics
Health Sciences Medicine and Dentistry Gastroenterology
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