Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6094041 | Gastroenterology | 2014 | 18 Pages |
Abstract
SIRT1-mediated activation of FGF21 prevents liver steatosis caused by fasting. This hepatocyte-derived endocrine signaling appears to regulate expression of genes that control a brown fat-like program in white adipose tissue, energy expenditure, and adiposity. Strategies to activate SIRT1 or FGF21 could be used to treat fatty liver disease and obesity.
Keywords
mRNAMCADSREBP-1FGF21Cpt1αVCO2PPARαBATSirt1VO2MEFFASmessenger RNAAdenovirusfatty acid synthaseWAT, White adipose tissuebrown adipose tissueCarbon dioxide productionMedium-chain acyl-CoA dehydrogenasefibroblast growth factor 21ObesityOxygen consumptionmouse embryonic fibroblastNADwild-typeNAD, nicotinamide adenine dinucleotideMetabolic homeostasisSterol regulatory element binding protein-1WATcarnitine palmitoyltransferase 1α
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Authors
Yu Li, Kimberly Wong, Amber Giles, Jianwei Jiang, Jong Woo Lee, Andrew C. Adams, Alexei Kharitonenkov, Qin Yang, Bin Gao, Leonard Guarente, Mengwei Zang,