Article ID Journal Published Year Pages File Type
6094041 Gastroenterology 2014 18 Pages PDF
Abstract
SIRT1-mediated activation of FGF21 prevents liver steatosis caused by fasting. This hepatocyte-derived endocrine signaling appears to regulate expression of genes that control a brown fat-like program in white adipose tissue, energy expenditure, and adiposity. Strategies to activate SIRT1 or FGF21 could be used to treat fatty liver disease and obesity.
Related Topics
Health Sciences Medicine and Dentistry Gastroenterology
Authors
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